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毒液和埃迪（汤姆·哈迪 Tom Hardy 饰）迎来至暗时刻。一边是人类神秘组织的穷追猛打，一边是外星共生体大军入侵地球，他们一心同体，花式解锁海陆空作战新形态。面对两边的疯狂追捕，这对亡命搭档将被迫做出毁灭性决定，为他们的最后一舞拉下帷幕。
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Handsome and successful Jim appears to have it all: he's married to the beautiful and supportive Lisa, has a healthy baby, and works a cool gig as the director of hardcore porno fare. Jim's seemingly perfect life starts to fall apart when he has an extramarital fling with an actress and the local Los Angeles vice cops …
